This is a multi-centre, randomised, double-blind, placebo-controlled trial of nebulised heparin in 256 intensive care unit patients who have a mild, moderate or severe acute lung injury.  These patients might have pneumonia, COPD, asthma, aspiration pneumonitis/pneumonia, pancreatitis, sepsis or septic shock, major surgery, drug overdose...etc

The study medication is 25 000 iu Heparin in 5ml 0.9% Sodium chloride, nebulised every 6 hours for the duration of mechanical ventilation up to maximum of 10 days.

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Update

Overall enrolment almost complete.  Bendigo Health study site now closed for enrolment.